Learning to Track Instances without Video Annotations

Tracking segmentation masks of multiple instances has been intensively studied, but still faces two fundamental challenges: 1) the requirement of large-scale, frame-wise annotation, and 2) the complexity of two-stage approaches. To resolve these challenges, we introduce a novel semi-supervised framework by learning instance tracking networks with only a labeled image dataset and unlabeled video sequences. With an instance contrastive objective, we learn an embedding to discriminate each instance from the others.

Weakly-Supervised Physically Unconstrained Gaze Estimation

A major challenge for physically unconstrained gaze estimation is acquiring training data with 3D gaze annotations for in-the-wild and outdoor scenarios. In contrast, videos of human interactions in unconstrained environments are abundantly available and can be much more easily annotated with frame-level activity labels. In this work, we tackle the previously unexplored problem of weakly-supervised gaze estimation from videos of human interactions.

Contrastive Syn-to-Real Generalization

Training on synthetic data can be beneficial for label or data-scarce scenarios. However, synthetically trained models often suffer from poor generalization in real domains due to domain gaps. In this work, we make a key observation that the diversity of the learned feature embeddings plays an important role in the generalization performance.

Exploring Synthesizable Chemical Space with Iterative Pathway Refinements

A well-known pitfall of molecular generative models is that they are not guaranteed to generate synthesizable molecules. Existing solutions for this problem often struggle to effectively navigate exponentially large combinatorial space of synthesizable molecules and suffer from poor coverage. To address this problem, we introduce ReaSyn, an iterative generative pathway refinement framework that obtains synthesizable analogs to input molecules by projecting them onto synthesizable space.

Proteina-Complexa: Scaling Atomistic Protein Binder Design with Generative Pretraining and Test-Time Compute

Protein interaction modeling is central to protein design, which has been transformed by machine learning with applications in drug discovery and beyond. In this landscape, structure-based de novo binder design is cast as either conditional generative modeling or sequence optimization via structure predictors ("hallucination"). We argue that this is a false dichotomy and propose Proteina-Complexa, a novel fully atomistic binder generation method unifying both paradigms.