Emerging applications in areas such as bioinformatics, data analytics, semantic databases and knowledge discovery employ datasets from tens to hundreds of terabytes. Currently, only distributed memory clusters have enough aggregate space to enable in-memory processing of datasets of this size. However, in addition to large sizes, the data structures used by these new application classes are usually charac- terized by unpredictable and fine-grained accesses: i.e., they present an irregular behavior.